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Original Article
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| Characterization of essential oil from the seed of Eucalyptus cloeziana and evaluation of its modes of medicinal potentials | ||||||
| Ololade ZS1,2, Olawore NO2 | ||||||
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1Department of Chemical and Food Sciences, Bells University of Technology, Ota, Nigeria
2Department of Pure and Applied Chemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria | ||||||
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| Ololade ZS, Olawore NO. Characterization of essential oil from the seed of Eucalyptus cloeziana and evaluation of its modes of medicinal potentials. Edorium J Infect Dis 2017;3:1–8. |
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Abstract
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Aims:
Different parts of Eucalyptus plants are widely used in medicine for the prevention and treatment of diseases. This study examined the phytochemicals and medicinal properties of the seed essential oil of E. cloeziana from Nigeria.
Methods: The essential oil was extracted by hydrodistillation and analyzed using gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). TPC, antioxidant, anti-inflammatory, antinociceptive and antimicrobial activities were measured by Folin-Ciocalteu’s, DPPH, FRAP, carrageenan, formalin and agar-well diffusion methods respectively. Results: The GC and GC-MS analyses revealed the presence of 33 phytochemicals making up 99.7% of the total percentage composition of the essential oil. The most abundant component was 1, 8-cineole (23.8%). The TPC was 199.18±0.0 µgmg-1 gallic acid equivalents. The antioxidant IC50 value of the essential oil was 2.8 µgml-1 and it was capable of scavenging free radicals in a range of 62.6–70.3%, the seed essential showed strong antioxidant activity with AAI higher than that of ascorbic acid. The reduction antioxidant potential of the essential oil was EC50: 1.5 µgml-1. The essential oil gave high anti-inflammatory with value of 68.8% and antinociceptive properties by inhibition in both neurogenic (81.3%) and inflammatory pain (80.3%). The essential oil was active against all the tested bacteria with high zones of inhibition (8.0–20.0 mm). Conclusion: Therefore, the seed essential oil of E.cloeziana is a sustainable and promising source of natural product with good therapeutic properties. | |
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Keywords:
Eucalyptus cloeziana, Medicinal properties, Phytochemicals, Seed essential oil
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Author Contributions
Ololade Z.S. – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Olawore N.O. – Substantial contributions to conception and design, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© 2017 Z.S Ololade et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
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